Serum Calcium-decreasing Factor, Caldecrin, Inhibits Receptor Activator of NF- B Ligand (RANKL)-mediated Ca Signaling and Actin Ring Formation in Mature Osteoclasts via Suppression of Src Signaling Pathway*
نویسندگان
چکیده
Background: Caldecrin is a serum calcium-decreasing factor and inhibits osteoclast differentiation. Results: Caldecrin inhibits RANKL-stimulated Ca2 entry, sealing actin ring formation and bone resorption of mature osteoclasts in a c-Src-dependent manner. Conclusion: Caldecrin is a negative regulator of RANKL-mediated osteoclast function. Significance: Caldecrin contributes to the understanding of the unique regulatory system for c-Src in osteoclasts.
منابع مشابه
Signaling and Actin Ring Formation in Mature Osteoclasts via Suppression of the Src Signaling Pathway
Background: Caldecrin is a serum calcium-decreasing factor and inhibits osteoclast differentiation. Results: Caldecrin inhibits RANKL-stimulated Ca 2+ entry, sealing actin ring formation and bone resorption of mature osteoclasts in a c-Src-dependent manner. Conclusion: Caldecrin is a negative regulator of RANKL-mediated osteoclast function. Significance: Caldecrin contributes to the understandi...
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